DHT is five times more potent than testosterone. Dihydrotestosterone (DHT) is made from testosterone by an enzyme. If you have a low level of SHBG, you may have a high level of free testosterone in your bloodstream. Due to the fact that the hair growth process seems to be a very energy-consuming process, it is most likely that the HPT axis hormones regulate the energy of hair follicle metabolism and mitochondrial functions. Androgens—such as testosterone (T); dihydrotestosterone (DHT); and their prohormones, dehydroepiandrosterone sulfate (DHEAS) and androstendione (A)—are the key factors in terminal hair growth. Previously, Pelage presented the results of a phase 2a clinical trial of 78 men and women with androgenic alopecia who applied a solution containing PP405 or a control to their scalps once daily for four weeks. Androgenic alopecia is commonly known as male pattern hair loss. A healthy scalp is essential for healthy hair growth, and niacinamide helps create the right environment for your follicles to thrive. Yes, caffeine can benefit most hair types and works for both men and women experiencing androgenetic alopecia. Serums and leave-in treatments stay on your scalp all day. Most people spend 30 seconds to a minute shampooing, then rinse. And because shampoo is something you're already using, it's an easy way to introduce caffeine into your routine. Don't get me wrong — caffeine shampoos can help. Shampoos provide a quick dose of caffeine but are rinsed off within minutes, limiting their impact. So, hormonal imbalance hair loss treatment must target the underlying endocrine disruption. The answer is yes—for body and facial hair. In females, testosterone is also present, although in smaller amounts. According to Reseachers, the relationship between testosterone and hair is both complex and misunderstood. Topical caffeine is generally safe for most people. Men often see a receding hairline and thinning at the crown, while women typically experience overall thinning and a widening part. Over time, this leads to thinner hair shafts, shorter growth cycles, and eventually, hair that doesn't grow back at all.